For the head of Syria is Damascus, and the head of Damascus is Rezin; and within threescore and five years shall Ephraim be broken, that it be not a people.
For the capital of Syria is Damascus, and the ruler of Damascus is Rezin; and within sixty-five years, Ephraim will be completely destroyed and will no longer exist as a nation.
God is declaring that Syria's power is limited to its human leaders, and the northern kingdom of Israel will be completely destroyed within 65 years.
📚 Historical Context
This prophecy was given around 735 BC during the Syro-Ephraimite War, when Syria (under King Rezin) and the northern kingdom of Israel (Ephraim) had formed an alliance against Judah. Isaiah was reassuring King Ahaz of Judah that these threatening enemies would not prevail, as their power was merely human and temporary.
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